"[Odysseus] fumigated the hall, house and court with burning sulfur to control pests."
Homer, The Odyssey
Civilization was founded on agriculture. The earliest cities grew up around 9,000 years ago when nomadic hunter-gatherers settled in Mesopotamia, herding animals and growing crops for the first time. But relying on the success of an annual crop was risky. poor weather, an infestation of insects, or crop diseases could ruin the harvest and starve a population. Humans are still unable to control the climate, but solutions to the other problems were proposed in the most ancient of times.
Early attempts to limit damage by pests were mostly physical interventions, such as crop rotation and the manual removal of grubs. The first evidence for a chemical agent comes from Sumeria in 2500 B.C.E., where elemental sulfur was used to ward off insects. The Sumerians had developed a sophisticated agriculture, employing irrigation and mass labor
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