Pharmacy

Wyatt Technology Corporation, a world leader in instrumentation for absolute macromolecular characterisation   and   software,   recently announced that its Mobius™ electrophoretic mobility instrument can measure precise protein charges. The innovative optical design of the Mobius boosts the sensitivity of mobility measurements, enabling protein net charge measurements, enabling protein net charge characterization at much lower concentrations than previously possible. Protein molecules carry charges that are influenced by their environment, amino acid sequence, ionic strength and the aqueous solvent pH in which they are dissolved. The net charge carried by protein molecules is of enormous scientific interest since it affects the behaviour of the molecules. As the ionic strength of the solution increases, for example, more counter ions are present in the vicinity of the protein molecules and the mobility generally decreases due to the electrophoretic effect.