VMMC VMMC Medical Solved Paper-2011

  • question_answer
    An example of competitive inhibition of an enzyme is the inhibition of

    A) cytochrome oxidase by cyanide

    B) hexokinase by glucose 6-phosphate

    C) carbonic anhydrase by \[C{{O}_{2}}\]

    D) succinic dehydrogenase by melonic acid          

    Correct Answer: D

    Solution :

              In competitive inhibition, the inhibitor molecules show structural similarity to the substrate molecule, so both compete to bind at the active site of enzyme. An example is succinic acid dehydrogenase which oxidises succinic acid to fumaric acid. If melonic acid is added, the activity of succinic acid dehydrogenase decreases.


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