DUMET Medical DUMET Medical Solved Paper-2010

  • question_answer
    Urea synthesis takes place primarily in liver because

    A)  \[N{{H}_{3}}\] and \[C{{O}_{2}}\] are present in liver only

    B)  hormone ADH is found in liver only

    C)  enzyme arginase is present in liver only

    D)  kidney is smaller than liver

    Correct Answer: C

    Solution :

    Urea synthesis takes place in liver through ornithine cycle. In liver, one molecule of \[C{{O}_{2}}\]is activated by biotin and combines with two molecules of \[N{{H}_{3}}\] in the presence of carbamyl phosphate synthetase enzyme and 2 ATP to form carbamyl phosphate and one molecule of \[{{H}_{2}}O\] is released. Carbamyl phosphate react with ornithine arid form citrulline that combines with another molecule of \[N{{H}_{3}}\] and form argininee. Arginme is broken into urea and ornithine in the presence of an enzyme arginase and water.


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