Directions : In the following question more than one of the answers given may be correct. Select the correct answer and mark it according to the code:
Which of the following belong to the coenzymes of pyruvate dehydrogenase complex? (1) Pyridoxal phosphate (2) Thiamine pyrophosphate (3) Tetrahydrophoiate (4) Lipoic acidA) 1, 2 and 3 are correct
B) 1 and 2 are correct
C) 2 and 4 are correct
D) 1 and 3 are correct
Correct Answer: C
Solution :
The oxidative decarboxylation of pyruvate in the formation of acetyl Co-A is catalysed by pyruvate dehydrogenase complex, an organized assembly of three kinds of enzymes. The three enzymes are pyruvate dehydrogenase component (\[{{E}_{2}}\]dihydrolipoyl transacetylase \[({{E}_{2}})\]and dihydrolipoyl dehydrogenase \[({{E}_{1}})\]. Thiamine pyrophosphare (TPP), lipoamide (lipoic acid) and FAD serve as catalytic cofactors (for \[{{E}_{2}},\text{ }{{E}_{1}},\text{ }{{E}_{3}}\]respectively) in addition to Co-A and NAD the stoichiometric cofactors.
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