A) citrulline and ammonia
B) citrulline and urea
C) Omithine and ammonia
D) Omithine and urea
Correct Answer: D
Solution :
Omithine cycle (urea cycle or Krebs and Henseleit cycle) occurs in liver with the help of 3 amino acids-Ornithine, citrulline and argenine. The enzymes required for this cycle are only present in liver. In this cycle urea is formed from 2 molecules of ammonia and one molecule of \[C{{O}_{2}}\]. \[Step\,{{I}^{st}}\] \[Ammonia+C{{O}_{2}}\xrightarrow{Mitochondria}\] Carbamoyl phosphate \[Step\text{ }I{{I}^{nd}}\] Carbamoyl phosphate + Omithine \[\xrightarrow{Cytoplasm}\] Citrulime \[Step\text{ }II{{I}^{rd}}\] Citrulline + Aspartate \[\xrightarrow[Synthetase\text{ }enzyme]{ATP}\] Argino succinate \[Step\text{ }I{{V}^{th}}\] Argino succinate \[\xrightarrow[\begin{smallmatrix} In\text{ }presence\text{ }of \\ enzyme\text{ }lyase \end{smallmatrix}]{Cleaves}\] Arginine + Fumarate Step Vth Arginine \[\xrightarrow[\begin{smallmatrix} With\text{ }the\text{ }help\text{ }of \\ enzyme\text{ }arginase \end{smallmatrix}]{Hydrolysed~~}\] Urea + Omithine
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