AFMC AFMC Solved Paper-2006

  • question_answer
    Kreb?s cycle was discovered by Krebs in pigeon muscles in 1940. Which step is called gateway step/link reaction/transition reaction in respiration?

    A) Glycolysis

    B) Formation of acetyl-coA

    C) citric acid formation

    D) ETS terminal oxidation

    Correct Answer: B

    Solution :

    If \[{{O}_{2}}\]is not available pyruvic acid undergo anaerobic respiration/fermenlation, but under aerobic condition the pyruvic acid enter into mitochondria and converted to Acetyl \[Co-A.\]Acetyl co-A functions as substrate entrant for Krebs cycle. So, a connecting link between glycolysis and Krebs cycle. Glycolysis is the process of breakdown of glucose (hexose sugar) to two molecules of pyruvic acid through a series of enzymes mediated reactions. It occurs in cytoplasm and is common both to aerobic and anaerobic respiration. Last product is pyruvic acid beside ATP generation. Krebs cycle or citric acid cycle or TCA cycle occurs in matrix of mitochondria. It is a stepwise oxiddtive and cyclic degradation of activated acetate derived from pyruvate.


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