A) Change of amino acid
B) Change of amino acid in chain of haemoglobin
C) Change of amino acid in both and chains of haemoglobin
D) Change of amino acid in either or -chain of haemoglobin
Correct Answer: B
Solution :[b] The sixth amino acid from the amino terminal end of chain of normal haemoglobin is glutamic acid while in sickle cell haemoglobin, it is valine. This replacement results a change in confirmation of the haemoglobin molecule and the RBC becomes sickle-shaped.
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