12th Class Biology Sample Paper Biology - Sample Paper-2

  • question_answer
    Haemophilia victims are mostly men. Very rarely women are affected by this disorder. Explain, why is it so.

    Answer:

    Haemophilia is genetic disorder caused by the presence of a recessive sex-linked gene (h) carried by X-chromosome. This is a defect of blood which prevents its clotting due to absence of anti-haemophiliac globulin. Hemophiliac recessive gene is located in the X-chromosome and controls the synthesis of a protein needed for the clotting of blood. This gene loses its ability for producing the coagulant due to mutation. A female becomes haemophilic only when both its X-chromosomes carry defective genes \[({{X}^{h}}{{X}^{h}})\]While in case of human males, a single gene for the haemophoilia defect is able to express itself as the Y-chromosome is devoid of any corresponding allele (\[{{X}^{h}}Y\]).


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