| (i) Failure of segregation of chromatids during cell division results in aneuploidy. |
| (ii) Chromosomal disorders are mainly determined by alteration or mutation in a single gene. |
| (iii) Thalassemia and cystic fibrosis are Mendelian disorders. |
| (iv) Sickle cell anaemia is an X-linked trait. |
| (v) Haemophilia is an autosome linked recessive disease. |
A) (i) and (iii)
B) (i), (iii) and (iv)
C) (iii) and (iv)
D) (ii) and (iii)
Correct Answer: A
Solution :
[a] Statements (i) and (iii) are correct. Sickle cell anaemia is an autosome linked recessive trait that can be transmitted from parents to the offspring when both the partners are carrier for the gene. Haemophilia is sex-linked recessive disease which shows its transmission from unaffected carrier female to some of the male progeny.
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