A) caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin.
B) caused by a change in a single base pair of DNA.
C) characterised by elongated sickle like RBCs with a nucleus.
D) an autosomal linked dominant trait.
Correct Answer: B
Solution :
[b] Sickle cell anaemia is an autosomal linked recessive trait that can be transmitted from parents to the offsprings when both the partners are carriers for the gene (or heterozygous). It is caused by a change in a single base pair of DNA. Sickle-cell anaemia is the name of a specific form of sickle-cell disease in which there is homozygosity for the mutation that causes HbS. Sickle-cell disease, or sickle-cell anaemia, is a life-long blood disorder characterised by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases the cells flexibility and results in a risk of various complications.
You need to login to perform this action.
You will be redirected in
3 sec
