A) Pyruvate to oxaloacetate
B) Pyruvate to acetyl CoA
C) Phosphoenol pyruvate to puruvate
D) Oxaloacetate to phosphoenol pyruvate
Correct Answer: B
Solution :
[b] The reaction sequence, glucose\[\to \] pyruvate \[\to \]acetyl CoA \[\to \] fatty acid is possible because, the reaction pyruvate \[\to \]acetyl CoA is catalysed by pyruvate dehydrogenase. The reaction is absolutely irreversible. Fat is degraded to acetyl CoA; this 2 carbon unit enters into the TCA cycle, where 2 carbon atoms are oxidised to 2 molecules of carbon dioxide; hence no net conversion of fat to carbohydrate is possible. However, glycerol part of neutral fat and propionyl CoA (3 carbon unit) from odd chain fatty acids can generate glucose; but quantitatively these are minimal sources.
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