A) an autosomal linked dominant trait
B) caused by substitution of valine by glutamic acid in the p-globulin chain of haemoglobin
C) caused by a change in base pair of DNA
D) characterised by elongated sickle like RBCs with a nucleus
Correct Answer: C
Solution :
Sickle-cell anaemia is caused by a change in a single base pair of DNA. It is a genetic disease reported from negroes. The individuals of sickle- cell anaemia are immune to malaria.
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