A) caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin
B) caused by a change in a single base pair of DNA
C) characterised by elongated sickle like-RBCs with a nucleus
D) an autosomal linked dominant trait
E) None of the above
Correct Answer: B
Solution :
Sickle-cell anaemia is an autosomal recessive disorder, where RBCs because sickle-shaped. It is due to the abnormal haemoglobin and homozygous genotype\[H{{b}^{S}}\text{-}H{{b}^{S}}.\] This disease is caused by a single gene which in heterozygous condition causes moderate sickling (sickle-cell trait) and In homozygous condition causes severe effect (sickle-cell anaemia).
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