A) Down's syndrome
B) Turner's syndrome
C) Sickle cell anaemia
D) Klinefelter's syndrome
Correct Answer: A
Solution :
| Abnormality | Cause | Characteristic |
| Down?s Syndrome | Trisomy of 21 st Autosome (45 A + XX/XY) | Mental retardation, prominent head, flattened nasal bridge, habitually open mouth and projecting lower lips |
| Turnes?s Syndrome | Non-disjunct Ion of sex chromosome  | Sterile female, webbed neck, no breast development, no menstruation or egg production |
| Klinefelter?s Syndrome | Non-disjunct ion of sex chromosome  | Gynecomastia in males. Nentally defective testes underdeveloped |
| Sickle cell Anaemia | Molecular gene mutation of gene HBA | Sickle- shaped RBCs, do not transport  efficiently |
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