A) The pro Bt Toxin inactivation requires temperature above human body temperature.
B) The Bt Toxin recognizes only insect specific target.
C) The Bt Toxin formation from pro Bt Toxin requires pH lower than that present in the human stomach.
D) Conversion of pro Bt Toxin to Bt Toxin takes place only in highly alkaline conditions.
Correct Answer: D
Solution :
The Bt Toxin protein exist as inactive protoxins but once an insect ingest the inactive toxin, it is converted into an active form of toxin due to the alkaline pH of the gut which solubilize the crystals. The activated toxin binds to the surface of midgut epithelial cells and creates pores that cause cell swelling and lysis and eventually causes the death of an insect.
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