• # question_answer 129) A codon is made up of A)  Single nucleotideB)  Two nucleotidesC)  Three nucleotidesD)  Four nucleotides

It was George Gamow, a physicist, who argued that since there are only 4 bases and if they have to code for 20 amino acids, the code should constitute a combination of bases. He suggested that in order to code for all the 20 amino acids, the code should be made up of three nucleotides. This was a very bold proposition, because a permutation combination of ${{4}^{3}}(4\times 4\times 4)$ would generate 64 codons; generating many more codons than required.