12th Class Biology Principle Of Inheritance And Variation

  • question_answer 8)
    Briefly mention the contribution of T.H. Morgan in genetics. 

    Answer:

    Thomas Hunt Morgan (1866-1945), an American geneticist and Nobel Prize winner of 1933, is considered as "Father of experimental genetics" for his work on and discovery of linkage, crossing over, sex linkage, criss cross inheritance, linkage maps, mutability of genes, etc. He is called fly man of genetics because of selecting fruit fly (Drosophila melanogaster) as research material in experimental genetics. It was largely due to his book, "The Theory of Gene", that genetics was accepted as a distinct branch of biology. In 1910, he discovered linkage and distinguished linked and unlinked genes. Morgan and Castle (1911) proposed "Chromosome Theory of Linkage" showing that genes are located in the chromosomes and arranged in linear order. Morgan and Sturtevant (1911) found that frequency of crossing over (recombination) between two linked genes is directly proportional to the distance between the two. 1% recombination is considered to be equal to 1 centi Morgan (cM) or 1 map unit. He worked on sex linked inheritance and reported a white eyed male Drosophila in a population of red eyed and proved that gene of eye colour is located on X-chromosome. The male passed its genes on X-chromosomes to the daughter while the son gets genes on X-chromosome from the female (mother). It is called criss-cross inheritance. 


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