Answer:
ADA enzyme is crucial for the immune system
to function. Deletion of the gene for acienosinedearninase results into ADA
deficiency.
In
some children, ADA deficiency can be cured by bone-marrow transplantation,
while in others it can be treated by enzyme replacement therapy, in which
functional ADA is given to the patient by injection. But the problem with both
of these approaches is that they are not completely curative.
It may recurrent in nature as in the
process of gene therapy, lymphocytes used are found not to be immortal in
nature and the patients required periodic infusion of such genetically engineered
lymphocytes.
For permanent cure, gene isolated
from the bone-marrow cells producing ADA is introduced into ceils at early
embryonic stages.
You need to login to perform this action.
You will be redirected in
3 sec