Biomolecules (DNA, and protein) exhibit
change in biological activity in anhydrous conditions, in non-aqueous or
anhydrous conditions the rigidity of protein and DNA increases due to the
weakening of hydrogen bond strength.It results into the change in overall free
energy, which is the combined effects of the exposure of the interior polar and
non-polar groups and their interaction with water.
In absence of aqueous condition, the
free energy change is negative, which is responsible for the denaturation of
Increasing strength of
hydrogen-bond causes water to primarily bond with itself and not to be
available for the hydrating structure of proteins or DNA, or for dissolving
On the other hand, if the
water-water hydrogen bond strength reduces then the exchange mechanisms
operating within the cell, such as hydrogen bonded water chains within and between
proteins and DNA, will become non-operational. It will further leads to the denaturation.
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